India-made drug shows promise in treating Covid heart damage | India News

A drug developed by the Defence Research and Development Organisation (DRDO) may reverse the heart damage caused by a protein in the SARS-CoV-2 virus, a study conducted in fruit flies and mice has found.
Researchers from the University of Maryland, Baltimore, US, identified how a specific protein in SARS-CoV-2, the virus responsible for Covid-19, damages heart tissue.
They then used the drug, called 2DG, to reverse the toxic effects of that protein on the heart.
Developed by Dr Reddy’s Laboratories in collaboration with DRDO, 2DG is an oral drug. The SARS-CoV-2 virus depends upon glycolysis or breakdown of glucose for energy. The drug hinders the process of glycolysis and prevents the growth of the virus.
People infected with Covid are at a significantly higher risk for developing inflammation of the heart muscle, abnormal heart rhythms, blood clots, stroke, heart attacks, and heart failure for at least a year after infection, compared to those who haven’t been infected with the virus, said the study.
The scientists, who are from the University of Maryland, then used a drug to reverse the toxic effects of the SARS-CoV-2 virus protein on the heart. Although 2DG has not been approved by the US food and drug administration to treat the disease, it’s currently in clinical trials for treatment of Covid in India, the study said. agencies

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